Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.892
Mechanism of Yiqi Huoxue Compound for Treatment of Acute Myocardial Infarction Based on Network Pharmacology
Abstract
Objective: To explore the potential mechanism of Yiqi Huoxue Compound for the treatment of acute myocardial infarction (AMI) through network pharmacology.
Methods: The main active compounds and related effect targets of Yiqi Huoxue Compound were searched and screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). The standard names of effect targets were obtained using Uniprot database, the disease-related targets were obtained using GeneCards, Online Mendelian Inheritance in Man (OMIM) and A Database of Gene-Disease Associations (DisGeNET), and the protein interaction network of AMI-related core targets was constructed through STRING database and Cytoscape software. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed for core targets using R language software.
Results: Based on the screening conditions, 93 effective compounds, 140 drug targets of Yiqi Huoxue Compound and 71 potential therapeutic targets related to AMI were obtained. A total of 92 entries were excavated by GO enrichment analysis (P<0.05), and 42 pathways related to AMI were screened out by KEGG pathway enrichment analysis (P<0.05).
Conclusion: Yiqi Huoxue Compound contains a variety of active compounds, which can exert its therapeutic effect through multiple targets and multiple signaling pathways. The research results can provide a modern theoretical basis for the clinical application and mechanism research of Yiqi Huoxue Compound.
Keywords
Yiqi Huoxue Compound; acute myocardial infarction; network pharmacology