Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1006
To Explore the Expression of ANGPTL4 in Patients with Acute Cerebral Infarction and Its Relationship with Carotid Atherosclerosis
Abstract
Objective- To investigate the expression of ANGPTL4 in patients with acute cerebral infarction (acute cerebral infarction) and its relationship with carotid atherosclerosis.
Methods- A total of 60 ACI patients who were admitted to this hospital from May 2015 to February 2017 were selected as the observation group, and 60 healthy individuals who underwent physical examination were selected as substitutes. The ANGPTL4 expression level was detected and compared by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) when the inserted subjects were admitted; at the same time, the biochemical indicators of the target subjects included TG, SOD, TC, HDL-C, LDL-C, FPG, FINS, TNF-ï¡ levels were detected and compared; and the relevant indicators of carotid atherosclerosis of the research subjects were measured mainly including carotid intima-media thickness (CIMI) and the largest area of plaque, and carotid artery was measured Atherosclerosis hardener and compare. After comparison, the correlation between the ANGPTL4 level and other indicators were studied, and the multi-element regression analysis of the factors affecting the serum IMT level was performed. Finally, the multi-factor regression analysis of the carotid atherosclerosis in ACI patients was performed.
Results- According to classification, the expression level of ANGPTL4 in the serum of patients in the observation group was significantly reduced (P <0.05); compared with subdivision, the levels of TG and SOD in the observation group were significantly reduced (P <0.05); and in the classification, the levels of TC, HDL-C, LDL-C, FPG, FINS, and TNF-ï¡ in the observation group were significantly increased (P <0.05); the carotid atherosclerosis area and Crouse score of the alternative study subjects were all significant increased (P <0.05); According to human analysis, the expression level of ANGPTL4 was positively correlated with TG and SOD levels (P <0.05), but negatively correlated with LDL-C, FPG, FINS, CIMT, the largest plaque area and the crossover level Correlation (P <0.05); the multivariate regression analysis of CIMT showed that ANGPTL4 and TNF-ï¡ are independent influencing factors of patients with CIMT; the multivariate regression analysis of carotid atherosclerosis in patients with ACI found that age, smoking History, hypertension and ANGPTL4 level are factors that affect carotid atherosclerosis (P <0.05).
Complications- The expression of ANGPTL4 is down-regulated in ACI patients. ANGPTL4 can protect ACI patients by stabilizing carotid atherosclerosis and inhibiting carotid atherosclerosis.
Keywords
ANGPTL4; acute cerebral infarction; expression; carotid atherosclerosis; correlation