Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1047
Analgesic effect of dexmedetomidine after laparoscopic hernia repair under general anesthesia in adults
Abstract
Objective: To investigate the analgesic effect of small amount of dexmedetomidine on adult patients undergoing laparoscopic hernia repair under general anesthesia. Methods: 124 adult patients undergoing laparoscopic hernia surgery under general anesthesia were randomly divided into control group and study group, 62 cases in each group Blood samples were collected at 4 h (T3) to measure inflammatory factors and immune function indexes. Pain and sedation scores at 6 h (T1), 12 h (T2) and 24 h (T3) after operation were observed and recorded. Meanwhile, the corresponding clinical indicators and agitation grade were compared. Results: compared with T0, the levels of CRP, TNF - α and cor in the control group increased at T1, T2 and T3, while the levels of CD4 +, CD8 +, CD4 + / CD8 + were decreased in the control group, while the contents of CRP, TNF - α and cor in the study group were increased at T1 and T2, while the contents of CD4 +, CD8 +, CD4 + / CD8 + in the study group were decreased (P < 0.05); compared with the control group, the contents of CRP, TNF - α and cor in the study group at T1, T2 and T3 were lower, while the contents of CD4 +, CD8 +, CD4 + / CD8 + were lower than those in the control group Compared with T1, the sedation scores at T2 and T3 in the control group were lower, and the pain and sedation scores at T2 and T3 in the study group were lower (P < 0.05); compared with the control group, the pain and sedation scores at T2 and T3 in the study group were lower (P < 0.05); the cough reaction and agitation scores of the study group were lower than those of the control group, and the agitation grade was better than that of the control group (P < 0.05). Conclusion: it has a good sedative and analgesic effect on adults after laparoscopic hernia repair.
Keywords
dexmedetomidine; adult; laparoscopic hernia repair under general anesthesia; analgesia