Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1048
Quantitative analysis and biological significance of HOXD10 and BFGF in glioma patients
Abstract
Objective
To investigate the expression and biological significance of gomeotic genes A13( HOXD10) and Basic fibroblast growth factor (BFGF) in gliomas. Method s 60 patients diagnosed with glioma were diagnosed in our hospital from Jan 2016 to December 2019 were chosen. The serum expression levels of S100, HOXD10 and Plexin B2 in the
experimental group (glioma patients) and the control group were measured by qRT PCR. And the expression of HOXD10 and BFGF in different stages of glioma patients was analyzed, the relationship with the degree of tumor malignancy was analyzed. Results Compared with those of the control group, the expression levels of HOXD10 and BFGF i n cerebrospinal fluid and plasma were significantly higher[blood: HOXA,13,(1.21 ± 0.14)vs 0; BFGF, (1.57 ± 0.33)vs 0 and cerebrospinal fluid: BFGF,(4.87 ± 1.13)vs 0; BFGF,(5.88 ± 0.21)vs 0].The larger the tumor volume, the lower the degree of differentiati on and the higher the expression level of HOXD10 and BFGF in the blood. The level of HOXD10 and BFGF protein in cerebrospinal fluid
was significantly higher than that in plasma. Conclusion The expression of HOXD10 and BFGF in brain glioma patients is up re gulated and is significantly correlated with the degree of
malignancy. The expression of HOXD10 and BFGF in cerebrospinal fluid is significantly increased and can be used as a marker of malignant degree of glioma.
Keywords
Glioma; HOXD10; BFGF; qRT-PCR