Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1062
Inhibitory Effects of Parecoxib Sodium on Hyperalgesia Induced by Anesthesia using Remifentanil in Combination with Sevoflurane
Abstract
AIM: To evaluate the inhibitory effects of parecoxib sodium on hyperalgesia induced by anesthesia using remifentanil in combination with sevoflurane.
MATERIALS AND METHODS: A total of 180 ASA I-II patients who received laparoscopic surgery from January 2017 to February 2018 were selected and randomly divided into a control group (group A) and a parecoxib sodium group (group B) (n=90). Intravenous inhalational anesthesia was performed. The same induction method was used by both groups. Anesthesia was maintained with 0.2-0.4 μg/(kg·min) remifentanil and 1.5%-3.5% sevoflurane. For group B, 40 mg parecoxib sodium was administered intravenously before suture. Mean arterial pressure (MAP), heart rate (HR) and oxygen saturation (SpO2) before surgery (T0), after surgery (T1), upon recovery (T2), immediately after extubation (T3), 10 min after extubation (T4) and 30 min after extubation (T5), as well as postoperative recovery time, extubation time, Ramsay score, verbal rating scale (VRS) score and adverse reactions were recorded.
RESULTS: The SpO2 values of both groups hardly changed at all time points. Group B had basically the same MAP and HR values at all time points (P>0.05). The MAP and HR values of group A at T2, T3, T4 and T5 were significantly higher than those at T0 and those of group B (P<0.05). The Ramsay score upon recovery and postoperative VRS score of group B were significantly better than those of group A (P<0.05). Group B did not suffer from respiratory depression, nausea, vomiting or agitation. In contrast, group A had 1 case of nausea and vomiting, and 18 cases of agitation. The incidence rate of agitation in group A significantly exceeded that of group B (P<0.05).
CONCLUSIONS: Parecoxib sodium has significant inhibitory effects on hyperalgesia after anesthesia using remifentanil in combination with sevoflurane, without increasing adverse
Keywords
Parecoxib Sodium, Remifentanil, Sevoflurane, Hyperalgesia