Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.1501
Comparison of the effects of intra-articular injection of ozone and sodium hyaluronate in the treatment of knee osteoarthritis on pain and knee joint function
Abstract
Objective: To compare the effects of intra-articular injection of ozone and sodium hyaluronate in the treatment of knee osteoarthritis on pain and knee joint function. Methods: A total of 90 patients with knee osteoarthritis admitted to our hospital from April 2018 to April 2020 were divided into the ozone group and the sodium hyaluronate group according to the random number table, with 45 cases in each group. The ozone group was treated with intra-articular ozone injection, and the sodium hyaluronate group was treated with intra-articular injection of sodium hyaluronate, both once a week for 5 weeks. The serum MMP-3, IL-1β, TGF-β levels before treatment, 5 weeks of treatment, pain VAS score, knee HSS score and adverse reactions of the two groups before treatment, 5 weeks of treatment, and 3 months after treatment were compared between two groups.
Results: The serum MMP-3 and IL-1β of the two groups were lower than before treatment, and serum TGF-β was higher than before treatment for 5 weeks (P<0.05). There was no significant difference in serum MMP-3, IL-1β and TGF-β between the ozone group and the sodium hyaluronate group after treatment (P>0.05). The pain VAS scores of the two groups of patients after treatment for 5 weeks and 3 months after treatment were significantly higher than those before treatment (P<0.05). There was no significant difference in pain VAS scores between the ozone group and the sodium hyaluronate group before treatment and 3 months after treatment (P>0.05). The pain VAS score of the ozone group after 5 weeks of treatment was lower than that of sodium hyaluronate Group (P<0.05). The HSS scores of the two groups of patients treated for 5 weeks and 3 months after treatment were significantly higher than before treatment (P<0.05). There was no significant difference between the HSS scores of the ozone group and the sodium hyaluronate group before treatment and 5 weeks of treatment (P>0.05). The HSS score of the sodium hyaluronate group was higher than that of the ozone group at 3 months after treatment (P <0.05). 46.67% of the patients in the ozone group experienced local soreness during the injection, which was significantly higher than 8.89% in the sodium hyaluronate group (P<0.05). 6.67% of patients in the ozone group had a transient heart rate drop, while the sodium hyaluronate group did not. The incidence of swelling and chills was lower in the two groups, and the difference was not statistically significant (P>0.05).
Conclusion: Intra-articular injection of ozone and sodium hyaluronate can effectively inhibit knee joint inflammation. The short-term effect of ozone is better, and the analgesic effect is more obvious; the long-term effect of sodium hyaluronate is more ideal, and the knee joint function is improved, and safer.
Keywords
Knee osteoarthritis; pain; knee joint function; intra-articular injection; ozone; sodium hyaluronate