Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1121
Live Birth Rate of Assisted Reproductive Technologyin Sonography-based Automated Volume Calculation (SonoAVC)
Abstract
Objective: To investigate the live birth rate of assisted reproductive technology in Sonography-based automated volume calculation (SonoAVC) and relative influencing factors.
Methods: 58 cases of infertile women underwent in vitro fertilization and embryo transfer (IVF-ET) in the reproductive medicine center of our hospital were retrospectively analyzed. Long term ovarian stimulation were performed using GnRH antagonist, oocyte maturation and blastocyst development were traced since the implement of ovarian stimulation, with 26 cases underwent conventional 2D ultrasonographyassigned to 2D group and 32 cases underwent SonoAVC to 3D group, two kinds of ultrasound techniques were compared to evaluate the ovarian volume and number of follicles. The effect of 3DSonoAVC on the periodic treatment of IVF using GnRH antagonist was evaluated in terms of clinical pregnancy rate and live birth rate. Oocyte maturity, OCCC score, fertilization, and cleavage rate were assessed among follicles of different diameters. Univariate and multivariate analysis of pregnancy outcomes in assisted reproductive technology affecting 3DSonoAVC were performed using Cox regressive model.
Results: Both 2D and 3D ultrasound techniques exerted no effect on pregnancy outcomes (P>0.05). Compared with 2D ultrasound technology, however, ovarian volume and number of follicles showed higher level in the detection of 3DSonoAVC technology with shorter counting time (P<0.05) and the proportion, follicle OCCC score, fertilization rate and cleavage rate of the muture oocyte with follicle diameter ≧16mm significantly increased (P<0.05). The factors affecting the pregnancy outcomes of 3D group were analyzed by Cox regressive model, in which the results of single factor analysis showed that age, infertility, endometrial thickness and quality of transplanted embryos were correlated with the pregnancy outcome of assisted reproductive technology in SonoAVC(P<0.05) , and the multi-factor analysis (both P<0.05) showed that infertile patients with transplanted embryo of excellent quality and 8 mm ≤ endometrial thickness ≤ 16 have a good pregnancy outcome in the detection of assisted reproductive technology in SonoAVC.
Conclusion: Assisted reproductive technology in SonoAVC showed no better pregnancy outcomes than conventional 2D ultrasonography. Age, embryo quality and endometrial thickness of HCG day were independent factors influencing clinical pregnancy outcome. The clinical pregnancy rate of patients with age ≥35 significantly reduced. Endometrial thickness of HCG day ranged from 8 to 16 mm could improve clinical pregnancy rate.
Keywords
3DSonoAVC; IVF-ET; long periodic GnRH antagonist treatment; Oocyte ability; live birth rate