Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1122
Efficacy of Minimally Invasive Endoscopic Neurosurgery (MIEN) and Urokinase Perfusion Treating Hypertensive Intracerebral Hemorrhage（HICH）
Abstract
Objective: To investigate the efficacy and prognostic value of minimally invasive endoscopic neurosurgery (MIEN) and urokinase perfusion treating hypertensive intracerebral hemorrhage（HICH）Methods: A total of 158 patients with HICH were recruited in this cohort from May 2016 to March 2017, with 80 cases underwent combined treatment of MIEN and urokinase perfusion employed as combined group and 78 cases underwent traditional craniotomy as control group. Hs-CRP, IL-11 and NLR before and after treatment of both groups were detected using ELISA, and a comprehensive set of clinicopathological data such as therapeutic effect, perioperative indicator, complication and prognosis were evaluated.
Results: NIHSS scores and serum hs-CRP, IL-11, and NLR of two groups decreased significantly after treatment (P<0.05), meanwhile, the combined group showed a lower level than the control group (P<0.05); In addition, the control group had a longer operation time, lower hematoma clearance rate, larger intraoperative blood loss, longer hospital stay, higher complication rate and lower GOS rate compared with the combined group(P<0.05). Poor prognosis of patients with hypertension history, age＞60, hematoma volume＞50 ml and GCS score ≤ 5 after combined treatment were considered as independent risk factor (P < 0.05).
Conclusion: Combined treatment of MIEN and urokinase perfusion could exert a more preferable curative effect on HICH than conventional surgery, reduce the incidence of complications as well as inflammation, and improve surgical process and prognosis
Keywords
MIENï¼›urokinaseï¼›HICHï¼›inflammationï¼›prognosis