Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.1505
Efficacy Of Chinese Herbal Medicine Fufang Banmao Capsule Combined With Chemotherapy For Non-Small Cell Lung Carcinoma: A Meta-Analysis Of Randomized Controlled Trials
Abstract
Objective: To conduct a meta-analysis on the efficacy and safety of Fufang Banmao Capsule combined with chemotherapy for non-small-cell lung carcinoma (NSCLC).
Methods: Eight databases will be searched for Fufang Banmao Capsule combined with chemotherapy in the treatment of NSCLC with retrieval time up to October 2020, including Web of science, The Cochrane Library, Pubmed, Embase, CNKI, VIP, CBM and Wangfang Data databases. Manual retrieval of references included in the study and supplementary retrieval of unpublished academic papers was performed. Two researchers selected literature, extracted data and evaluated the included studies independently, and we conduct data analysis with RevMan5.3 software and Stata15 software.
Results: 10 studies involving 826 patients were included. Results showed that the disease control rate of Fufang Banmao Capsule combined with chemotherapy was better than that of chemotherapy alone [RR=1.14,95%CI(1.05,1.25),P=0.002], the adverse reaction rates of digestive tract reaction, abnormal liver function, abnormal liver and kidney function, anemia and leukopenia were all lower than that of chemotherapy alone, and quality of life improvement rate was better than that of chemotherapy alone [MD=1.56,95%CI(1.24,1.98), I2=0%, P=0.0002].
Conclusion: Based on the existing evidence, Fufang Banmao Capsule combined with chemotherapy has a positive effect on NSCLC compared with chemotherapy alone, with lower adverse reaction rate and better improvement rate of life quality than chemotherapy alone. However, because of the small number of included studies and generally low quality, the findings need to be treated with caution.
Keywords
Non-small cell lung carcinoma; Fufang Banmao Capsule; Meta-analysis