Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.906
Expression of miR-19b-3p and its relationship with cognitive function before and after lung cancer resection under thoracic epidural anesthesia combined with intravenous anesthesia
Abstract
Objective: To investigate the expression of miR-19b-3p and its relationship with cognitive function before and after lung cancer resection under thoracic epidural anesthesia combined with intravenous anesthesia. Methods: Altogether 194 patients undergoing lung cancer resection in our hospital were selected as research objects and randomly divided into two groups. Patients in the intervention group was given thoracic epidural anesthesia combined with intravenous anesthesia, while patients in the control group was given intravenous anesthesia alone. The anesthetic effect (operation time, awakening time, extubation time, recovery time) of the two groups of patients was observed and recorded. Ramsay sedation score, VAS score, MMSE score and incidence of postoperative cognitive dysfunction (POCD) in different time periods were compared. The expression level of serum miR-19b-3p before and after operation was observed. Cox regression analysis was applied to analyze postoperative prognostic factors in lung cancer patients. Results: The anesthesia effect of patients in the intervention group was notably better than that of the control group (p<0.05). There was no difference in t1 in terms of Ramsay sedation score and VAS score between the two groups, while Ramsay sedation score and VAS score in t2 and t3 of patients in the intervention group were remarkably better than those in the control group (p<0.05). MMSE score at 1 d and 3 d after operation of patients in the intervention group was notably better than that in the control group (p<0.05). The incidence of POCD in the intervention group was notably lower than that in the control group (p<0.05) at 1 d and 3 d after operation. Age, high miR-19b-3p expression, intravenous anesthesia, awakening time and recovery time were all important related factors when POCD occurred. Conclusion: Thoracic epidural anesthesia combined with intravenous anesthesia has good curative effect and response in lung cancer resection patients. It can produce great sedative and analgesic effects, reduce the incidence of POCD, and decrease the expression of miR-19b-3p in serum of lung cancer patients.
Keywords
thoracic epidural anesthesia combined with intravenous anesthesia, lung cancer resection, miR-19b-3p, cognitive function