Volume 29, Issue 4, 2020


DOI: 10.24205/03276716.2020.827

Establishment of Reference Intervals for Complete Blood Count Parameters During Normal Pregnancy in Second Trimester


Abstract
Background: Pregnant women belong to the normal population, they have their unique features, including undergoing a series of bodily changes during the pregnancy. However, there are no reference intervals of pregnant women in China. In this study, reference intervals for complete blood count parameters of Chinese pregnant women was established. Methods: Healthy pregnant women took the blood tests at second trimesters. Healthy adult women took the tests at the same time. All blood samples were tested on Sysmex XE-2100.The following CBC parameters were analyzed: red blood cell count (RBC), hemoglobin (HB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count (PLT), white blood cell count (WBC), and leukocyte differential classification. Determine whether there is a difference between the pregnant women and healthy adult women. Reference intervals were calculated based on the x± 1.96s. Results: The RBC count, HB concentration, HCT and PLT of pregnant women were significantly lower than values for healthy adult women (p<0.001). MCV, MCH, MCHC,and WBC count in pregnant women were significantly higher than in healthy adult women (p<0.001). The percentage of NEUT increased significantly; the percentage of MONO increased slightly; and the percentages of LYMPH, EO, and BASO all decreased accordingly. The reference intervals of which for RBC was 3.19-4.58×1012/L , Hb was 100.04-139.43 g/L, HCT was 0.32-0.38 and for PLT was 91.27-281.32×109 /L. The reference intervals of which for MCV was 81.40-99.83fL, MCH was 24.95-36.85pg, MCHC was 320.90-358.90g/L. The reference intervals of which for WBC was 5.20-13.59×109 /L.NEUT% was 63.34%-84.51%, LYMPH% was 10.21%-29.18%, MONO% was 2.96%-7.91%, EO% was 0%-2.36%, BASO %was 0%-0.46%. Conclusions: There are significant difference between the pregnant women and healthy adult women for CBC. The changes of CBC parameters during pregnancy are described. The reference intervals for pregnant women in the second trimester are determined in this study

Keywords
complete blood count; pregnancy; reference interval

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