Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.828
Risk factors and their predictive value of hepatorenal syndrome in patients with decompensated cirrhosis
Abstract
Objective: The purpose of this study was to define risk factors and their predictive value for hepatorenal syndrome (HRS) in patients with decompensated cirrhosis.
Methods: A total of 246 patients with decompensated liver cirrhosis were included. Subjects were divided into HRS and non-HRS groups according to the presence or absence of concurrent HRS or not. Sociodemographic and clinical characteristics or various biochemical parameters were compared between both groups, including gender age etiology and international normalized ratio (INR) level, alanine aminotransferase (ALT), aspartateaminotransferase (AST), alkaline phosphatase (ALP), potassium ion (K+), chloride ion (Cl ),sodium ion (Na+), Calcium (Ca2+) urea, nitrogen(BUN), total bilirubin (TBil), albumin (Alb), prothrombin time (PT), uric acid (UA), creatinine (Scr) and CysC.
Results: The levels of CysC ,Scr,AST, ALP and Na+ were statistically significant between two groups (P 0.05). Logistic regression analysis showed that CysC,Scr,AST,ALP and Na+ were the significant factors for predicting the occurrence of HRS. Multivariate Logistic regression analysis showed that CysC and Scr were independent risk factors affecting HRS.The area under the ROC curve (AUC) of CysC, Scr and BUN were 0.756, 0.673 and 0.661, respectively.
Conclusion: CysC and Scr seem to be independent risk factors for the development of HRS.While CysC shows better clinical predictive value for patients with decompensated liver cirrhosis complicated with HRS when comparing with Scr and BUN
Keywords
Cirrhosis; Hepatorenal syndrome; Cystatin C.