Volume 29, Issue 2
DOI: 10.24205/03276716.2020.393
EFFECT AND MECHANISM OF MUSIC THERAPY ON NEURAL RESTORATION IN PATIENTS WITH EPILEPSY
Abstract
Epilepsy is a chronic disease of the nervous system that torments the body and mind of the patient. Despite the availability of some treatments, epileptic patients are still troubled by treatment effect, complications and high cost, to name but a few. This calls for effective and economical method for the treatment of epilepsy. This paper explores the effect of music therapy on the neural restoration of epilepsy and its neural mechanism. A total of sixty 6-week-old healthy male mice were randomly divided into epilepsy group, music group, white noise group, and healthy group. Status epilepticus(SE) was induced in the mice of the first three groups through pilocarpine injection. Mozart music was played to the music group for 3h a day, while white noise played to the white noise group. For the other two groups, no music or white noise was played. After 8 weeks, the effects of music therapy on epilepsy in mice were investigated by observing the frequency, duration, and intensity of epileptic seizure. The results show that the mice in the music group had fewer frequencies, less duration, and reduced intensity of epileptic seizures after several weeks of treatment than those in the other groups. This means music therapy has a relieving effect on epilepsy. The research is of great significance for the clinical treatment of epilepsy.
Keywords
Music, Epilepsy, Electroencephalogram (EEG), Pilocarpine.