Volume 29, Issue 3
DOI: 10.24205/03276716.2020.717
A Systematic Review and Meta-analysis of Panaxosides in the Treatment of Glomerulonephritis
Abstract
Objective Systematic evaluation of the efficacy of panaxoside in the treatment of glomerulonephritis.
Method The retrieve database includes China National Knowledge Infrastructure (CNKI), VIP Chinese sci-tech journal database (VIP), Wanfang database (Wanfang Data), and China Biology Medicine disc (CBM), with the keywords of "ginsenoside", "panaxoside", "glomerulonephritis", "nephritis" and "chronic glomerulonephritis". The retrieved time is limited from January 2000 to June 2020, and the language is limited to Chinese. Review Manager 5.3 was used to deal with the data, the 24 h urine protein, serum creatinine, blood glucose, body weight, serum glucose, total cholesterol and triglyceride were used as the evaluation indexes.
Results A total of 8 articles and 246 patients were included. The results of meta-analysis showed that panaxoside could effectively reduce the content of 24-hour urinary protein [MD = -31.81, 95%CI (-38.74, -24.88), P<0.00001], serum creatinine [MD = -21.89, 95%CI (-30.95, 12.840, P<0.00001], blood glucose [MD = -4.97, 95%CI (-8.66, -1.28), P=0.008], serum glucose [MD = -3.19, 95%CI (-3.66, -2.710, P<0.00001], and triglyceride [MD = -0.72, 95%CI (-0.82, 0.620, P<0.00001]. Conclusion Panaxoside has a good curative effect in the treatment of glomerulonephritis, which provides some reference for the clinical application.
Keywords
Panaxoside; Glomerulonephritis; Meta; Curative effect