Volume 29, Issue 3
DOI: 10.24205/03276716.2020.724
Effects of Single Epidural Injection of Morphine in Combination with Intravenous Injection of Dezocine on Analgesia After Caesarean Section and Serum Levels of 5-Hydroxytryptamine and Prolactin Running Title: Analgesia After Cesarean Section
Abstract
Objective: To analyze the impacts of single epidural injection of morphine in combination with intravenous injection of dezocine on analgesia after cesarean section and serum levels of 5-hydroxytryptamine and prolactin.
Methods: Eighty puerperas who underwent cesarean section from January 2016 to November 2018 were enrolled. They were distributed into an observation group and a control group by following random number method (n=40). The control group received single epidural injection of morphine, and the observation group received single epidural injection of morphine combined with intravenous injection of dezocine. The visual analogue scale (VAS) was utilized to evaluate postoperative analgesic effects. Serum levels of 5-hydroxytryptamine and prolactin were measured by ELISA and chemiluminescence assay before and 6 h, 12 h, 24 h and 48 h after surgery. The incidence rates of postoperative adverse reactions were observed.
Results: The postoperative VAS scores of both groups gradually decreased with extended time. The scores of the observation group 6 h, 12 h, 24 h and 48 h after surgery were significantly less than control group (P<0.05). Level of serum 5hydroxytryptamine of the observation group (6 to 48 h) after surgery were significantly less than those of the control group (P<0.05), whereas the prolactin levels were significantly higher (P<0.05). No case suffered from respiratory depression after surgery. The frequency of nausea, vomiting, dizziness and pruritus in the observation group were significantly lower as compare to the control group (P<0.05).
Conclusion: Single epidural injection of morphine in combination with intravenous injection of dezocine had better analgesic efficacy and higher safety after cesarean section than those of morphine alone for patient-controlled analgesia. The serum levels of prolactin and 5-hydroxytryptamine significantly increased after surgery, which may inhibit postpartum depression, being beneficial to postoperative recovery and early lactation.
Keywords
Epidural space; morphine; dezocine; cesarean section; 5- hydroxytryptamine; prolactin