Volume 29, Issue 3
DOI: 10.24205/03276716.2020.926
Correlation of Serum C-reactive Protein, IL-6, Blood Lipid and Blood Glucose in Patients with Type 2 Diabetes Mellitus Complicated with Pulmonary Tuberculosis
Abstract
Objective: To explore the correlation of serum C-reactive protein, IL-6, blood lipid and blood glucose in patients with type 2 diabetes mellitus (DM) complicated with pulmonary tuberculosis (PTB). Methods: In this experiment, 74 patients with DM complicated with PTB admitted to our hospital from March 2016 to April 2019 (research group, RG) and 30 cases of healthy physical examination at the same time (control group, CG) were collected as study objects. The expressions of C-reactive protein, IL-6, blood glucose and blood lipid were observed in patients with DM complicated with PTB. The predictive value of C-reactive protein, IL-6, blood glucose and blood lipid in DM complicated with PTB was analyzed. The correlation of clinical pathology of DM complicated with PTB was analyzed. The correlation between the expression levels of C-reactive protein, IL-6 and blood glucose, blood lipid was observed. Results: The expression of each index in RG was significantly higher than that in CG (P < 0.05). According to ROC curve analysis, the area under C-reactive protein curve, IL-6 curve, FPG curve, HbAlc curve, TC curve, LDL-C curve and HDL-C curve were 0.628, 0.767, 0.742, 0.780, 0.737, 0.726 and 0.721 respectively. The expression levels of C-reactive protein and IL-6 were closely related to cough, hemoptysis and staging of patients with DM complicated with PTB (P < 0.05). Pearson test showed that C-reactive protein was positively correlated with blood glucose (r = 0.655, p < 0.001), and IL-6 was positively correlated with blood glucose (r = 0.567, p < 0.001). Conclusion: C-reactive protein, IL-6, blood lipid and blood glucose are abnormally expressed in patients with DM complicated with PTB. Creactive protein, IL-6, blood lipid and blood glucose may be involved in the development and progression of DM complicated with PTB, which is expected to be an excellent index for the diagnosis and treatment of DM complicated with PTB in the future.
Keywords
diabetes mellitus (DM), pulmonary tuberculosis (PTB), serum C-reactive protein