Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1075
Treatment of Tibial Traumatic Osteomyelitis with Negative Pressure Closure Drainage Combined with Open Bone Grafting or Bone Migration and Its Effect on The Levels Of CRP, TNF-α and IL-6 in the Serum
Abstract
Objective To observe the effect of negative pressure closure drainage combined with open bone grafting or bone migration in the treatment of tibial traumatic osteomyelitis.
Methods 86 cases of tibial traumatic osteomyelitis admitted to our hospital from September 2017 to September 2018 were randomly divided into control group and observation group, 43 cases each. Debridement, open bone grafting or bone migration were given to the control group. The observation group was treated with negative pressure closed drainage on the basis of the control group. In addition, the serum components such as CRP, TNF-α, IL-6 of the control group and observation group were detected respectively after surgery
Results observation group granulation cover wound, fracture healing time is shorter than the control group, fracture healing rate is better than the control group, the difference has statistical significance (P < 0.05). By comparing serum CRP, TNF-α, IL-6 levels before and after treatment in the two groups, it was found that the observation group was lower than the control group (P < 0.05, respectively). Serum CRP, TNF-α, IL-6 levels were significantly (P < 0.05).
Conclusion The treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone displacement has a good effect on fracture healing and is worth popularizing
Keywords
Tibia; Bone removal; Traumatic osteomyelitis; Negative pressure closure drainage; CRP; TNF-α; IL-6