Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.809
Diagnostic Value and Clinical Significance of Simultaneous Amplification and Testing Combined with Serum hs-CRP and TNF-α For Children with Mycoplasma Pneumoniae Infection
Abstract
Aim: To examine simultaneous amplification and testing (SAT) diagnostic significance and clinical meanings, together with a high-sensitivity serum C-reactive protein(hs-CRP) and a TNF-α factor in children infected by Mycoplosma pneumoniae.
Methods, From June 2018 to July 2019, 400 pediatric pneumonia patients were chosen as research objects, classified as study groups (children with infected M. pneumoniae, n = 179), and control groups, n= 221. In the serum hs-CRP and TNF-α levels, enzyme-linked immunocompromised tests were used. The receiving operating property curve for serum hs-CRP and TNF-α diagnostic values in children with M was used. Infection of pneumonia. Furthermore, the diagnostic efficacy of SAT, Serum Hs-CRP and TNF-α in children with M is based on serologic antibody testing findings. Analyzed pneumoniae infection.
The findings showed a substantial rise in the serum levels hs-CRP and TNF-α in the study group compared with the levels in the control group (P<0.05). The values, specificity and precision for hs-C RPD in M diagnosis, were 65.00%, 57.00% and 63.00%, respectively. In infectious pneumonia in children 58.00%, 61.00% and 60.00% were for TNF-α, 86.00%, 72.00% and 80.00% were for SAT and 97.00% for 96.00% and 98.00% for combined identification. Combined detection was significantly more efficient, accurate and precise than single detection (P<0.05).
In conclusion, SAT in combination with Serum hs-CRP and TNF-α has an early diagnosis of M with a high application benefit. Infection with pneumoniasis in children and early diagnosis can be helpful.
Keywords
simultaneous amplification and testing, hs-CRP, TNF-α, Mycoplasma pneumoniae infection in children, diagnostic value, clinical significance.