Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1080
Correlation Between ER, PR, p53, Ki-67 Expressions and High-Risk HPV Infection in Patients with Different Grades of Cervical Intraepithelial Neoplasia
Abstract
Objective: To explore the correlations of high-risk human papillomavirus (HPV) infection with the expressions of estrogen receptor (ER), progesterone receptor (PR), p53 and Ki-67 in patients with different grades of cervical intraepithelial neoplasia (CIN).
Methods: A retrospective study was conducted on 140 CIN specimens preserved in our hospital from June 2016 to June 2018, including 40 cases in grade 1, 50 cases in grade 2, and 50 cases in grade 3. The expressions of ER, PR, p53 and Ki-67 were determined using immunohistochemistry, and the high-risk infection was detected by fluorescence quantitative polymerase chain reaction. Besides, the correlation analysis was performed.
Results: Among the 140 specimens, low-grade squamous intraepithelial lesion specimens showed an HPV16-positive rate of 27.5% and an HPV18-positive rate of 25.0%, high-grade squamous intraepithelial lesion a (HSILa) specimens exhibited an HPV16-positive rate of 64.0% and an HPV18-positive rate of 60.0%, and HSILb specimens displayed an HPV16-positive rate of 90.0% and an HPV18-positive rate of 92.0%, with statistically significant differences (P<0.05). The positive rates of HPV16 and HPV18 were not significantly correlated with the age and tissue differentiation degree of patients (P>0.05). With the increase in CIN grades, the positive expression rates of ER, PR, p53 and Ki-67 in the tissue specimens were also significantly elevated, showing statistically significant differences (P<0.05). The correlation analysis results revealed that the positive rates of HPV16 and HPV18 were significantly positively correlated with the positive expression rates of ER, PR, p53 and Ki-67 (P<0.05).
Conclusion: The positive rate of HPV infection is raised with the increase in CIN grade, which is also accompanied with the elevation of the positive expression rates of ER, PR, p53 and Ki-67, and there are positive correlations among them.
Keywords
cervical intraepithelial neoplasia; HPV infection; correlation; p53; Ki-67