Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1084
Correlation Analysis of Serum Uric Acid with Insulin Resistance in Patients with Type-2 Diabetes
Abstract
Objective: To evaluate correlations between SUA and insulin resistance in type-2 diabetes (T2DM) patients.
Methods: A total of 208 T2DM who were admitted between January 2015 and December 2017 to the Department of Endocrinology, Nanjing University of Chinese Medicine were analyzed herein. The selected parameters, including age, BMI, SUA, total cholesterol, TG, LDL-C, FBG, PBG, HbA1c, FINS and HOMA-IR, were estimated. Patients were categorized into a compliance group (HbA1c <7%) and a non-compliance group, (HbA1c ≥7%). For the HOMA-IR and SUA levels, Q1-Q4 was used to compare the indicators in each group. Furthermore, correlation and linear regression analysis were performed.
Results: Patients who had abnormal BMI and were obese presented with significant levels (p<0.05) of the selected biochemical parameters. Non-compliant patients had significantly higher (P<0.05) SUA, FBG and PBG levels, when relative to the compliance group. For HOMA-IR groups, from the Q1 to Q4 group, the BMI, FBG, TG and SUA levels gradually increased (P<0.05). For the SUA groups, from the Q1 to Q4 group, the BMI, FBG, PBG, TG and FINS levels increased, while age gradually decreased (P<0.05). In a correlation analysis, the SUA levels, and FBG, HbA1c, PBG, TGs, FINS, BMI and HOMA-IR had a positive correlation (P<0.05). The regression analysis showed that FBG, PBG, TGs, FINS, BMI, HbA1c and HOMA-IR are correlated to SUA levels (P<0.05).
Conclusion: The increase in SUA in T2DM is linked with the increase in insulin resistance caused by obesity, and abnormal glucose and lipid metabolism.
Keywords
Type-2 diabetes mellitus; Serum uric acid; Insulin resistance; Body mass index