Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1126
Effect of Atorvastatin on Expression of Inflammatory Cytokines and Osteopontin in Renal Transplant Rats
Abstract
Purpose: To investigate the effect of atorvastatin on the expression of inflammatory cytokines and osteopontin in renal transplant rats. Methods: 40 adult male SD rats of inbred line were purchased as renal transplant donors and 40 adult male SD rats of inbred line as renal transplant recipients. The SD rats were randomly divided into study group and control group. The control group received conventional triple therapy. The study group was treated with atorvastatin in combination based on control group. The correlated clinical indexes, expression levels of osteopontin and inflammatory cytokines of rats after operation were compared between the two groups.
Results: There was no significant difference in the levels of TC and TG of rats after operation between the two groups (P > 0.05), but the levels of SCr, BUN and 24h urine protein in the study group were significantly lower than those in the control group (P < 0.05); the expression levels of osteopontin in the study group were significantly lower than those in the control group at different time points after operation (P < 0.05); the expression levels of IL-2, IL-6, IL-17 and TNF-α inflammatory cytokines in the study group were significantly lower than those in the control group (P < 0.05); the expression level of IL-10 was significantly higher than that of the control group (P < 0.05).
Conclusion: Atorvastatin can effectively reduce the expression of inflammatory cytokines and osteopontin in rats after renal transplant, which is beneficial to reduce the interstitial inflammation after renal transplant and the rejection of cells after renal transplant.
Keywords
Atorvastatin; Renal transplant; Inflammatory cytokines; Osteopontin