Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1169
Protective Effect of Ligustrazine on Osteoporosis in Diabetic Rats
Abstract
To study the protective effect of Ligustrazine on osteoporosis in diabetic rats. Diabetic osteoporosis rat model was used. SD rats were half male and half female, 180-220g. 50 rats meeting the research conditions provided by the Institute were divided into two groups, with an average of 25 rats in each group. Group A did not take any intervention measures before treatment, group B was Ligustrazine intervention treatment group. Observe the general situation of rats, blood biochemical indicators, bone metabolism indicators and other related indicators, and carry out logical analysis, and finally statistical analysis of the data. In general, there was no significant difference between group A and group B in age before treatment, BMI, menopause age, blood Ca, P, Mg, PTH, BMD (P > 0.05). In the aspect of bone metabolism indexes, the bone metabolism indexes (OC, PINP, β- CTX, 25 (OH) D3) in group B were lower than those in group a before treatment, the difference was statistically significant (P <0.008). There was no significant difference between the two groups before and after treatment (P > 0.05). From the perspective of protection effect, 68% of the protection effect is good, 20% of the protection effect is general, 6% of the protection effect is not good, and 6% of the protection effect is not good. Ligustrazine has a good protective effect on osteoporosis in diabetic rats. Bisphosphonates can reduce bone metabolism and enhance bone stability in PMOP and T2DM rats.
Keywords
Ligustrazine, Diabetes, Osteoporosis, Bone Protection