Volume 30, Issue 1, 2021
DOI: 10.24205/03276716.2020.2026
Short-term efficacy of surgery combined with intrapleural perfusion with hyperthermic chemotherapy in NSCLC patients with MPE
Abstract
Backgrounds: To investigate the short-term efficacy and safety of surgery combined with intrapleural perfusion with hyperthermic chemotherapy (IPHC) in non-small-cell lung cancer (NSCLC) patients with malignant pleural effusion (MPE).
Methods: A total of 54 NSCLC patients with MPE were enrolled(26 in treatment group vs 28 in the control group). The patients in the treatment group underwent surgery combined with 3 IPHC for 60 minutes each time. The control group was treated with traditional intrathoracic perfusion.
Results: The control rate of pleural effusion at 4 weeks, 2 months and 3 months in the treatment group was 92.31%, 84.21% and 83.33%; the rate in the control group was 42.86%, 50.00% and 38.89% (P<0.05). The improvement rate of karnofsky performance
status (KPS) score in the treatment group(80.77%) was higher than that in the control group(46.43%) (P < 0.05). Conclusions: The short-term effect of surgery combined with IPHC is effective and safe in the treatment of NSCLC patients with MPE
Keywords
intrapleural perfusion with hyperthermic chemotherapy; video-assisted thoracoscopy surgery; lung cancer; malignant pleural effusion