Volume 30, Issue 2, 2021
DOI: 10.24205/03276716.2020.4042
Comparative study of ADC values and breast cancer subtypes in diffusion-weighted (DM) imaging
Abstract
Histological subtypes of breast cancer are of great significance in assessing tumor characteristics. Our study intends to assess compare ADC values and histological subtypes of breast cancer in diffusion weighted (DM) imaging. This study retrospectively analyzed breast cancer patients from December 2016 to February 2018. 262 breast cancer patients were examined by DWI (b = 500s / mm2) and measured for lesions. Spearman correlation analyzed the relationship between ADC value and different degrees of differentiation. ADC value showed significant difference between ductal carcinoma in situ and invasive carcinoma (p <0.05) and also between ductal carcinoma in situ, tubule and sieve cancer (p <0.05). The maximum WDu ADC value of PR-positive tumors was significantly reduced compared to PR-negative tumors (p <0.05) and the maximum WDu of HER-2 positive tumors was significantly elevated compared to HER-2 negative (p <0.05) without difference of Ki-67 status. ADC values showed significant difference in breast cancers with different differentiation (p <0.05) and were correlated with differentiation degrees of lesions (rs = -0.272, P <0.05). ADC value has certain significance for judging the histological type and differentiation degree of breast cancer before surgery. The ADC value of ductal carcinoma in situ and low-differentiated tumor is low and the maximum WTa of HER-2 positive tumor is significantly higher HER-2 negative.
Keywords
DWI, ADC, breast cancer, subtype