Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.840
Experimental Study on the Changes of Sphingosine 1-Phosphate and Matrix Metalloproteinases 3 in Serum of Patients with Osteoarthritis
Abstract
Objective: To explore the level changes and clinical significance of matrix metalloproteinase-3 (MMP-3) and sphingosine 1-phosphate (S1P) in the patients with osteoarthritis (OA).
Methods: Thirty-six patients with early-stage OA and thirty-two patients with late-stage OA were selected. Besides, seventy-two age-matched healthy subjects who had the physical examination were also included as the control group. And the differences between S1P and MMP-3 levels in the three groups were also observed to investigate the correlation between S1P and MMP-3.
Results: In the early-stage OA group, the S1P and MMP-3 levels in serum are 0.118 ± 0.04 and 207.9 ± 19.70 pg/mL; S1P and MMP-3 levels in the late-stage OA group are 0.171 ± 0.03 and 292.23 ± 27.4 pg/mL. These values are both obviously higher than those in control group (S1P: 0.065 ± 0.02 pg/mL, MMP-3: 59.62 ± 8.38 pg/mL, P < 0.05). Analysis of spearman correlation revealed the positive correlation between levels of S1P and MMP-3 (r = 0. 740).
Conclusion: The levels of S1P and MMP-3 showed an increase in the serums of OA patients; and the increased levels of S1P will result in the increased levels of MMP-3 and thus lead to OA, which is more obvious in late-stage patients.
Keywords
Osteoarthritis; Early-stage; Late-stage; Serum; Sphingosine 1-phosphate; Matrix metalloproteinases 3; Correlation