Volume 30, Issue 2, 2021
DOI: 10.24205/03276716.2020.4044
NSMF acts as a novel biomarker in glioma
Abstract
Glioma is the most prevalent and deadly tumor of the central nervous system (CNS) in adults. However, Specific markers which are applied to diagnose and track the disease is still undiscovered. We found that the expression of NSMF is lowly expressed in glioma tissues and negative related to tumor grade and survival time, expressing databases by multiple glioma mRNA. Furthermore, we use The Human Protein Atlas discovered that glioma tissue NSMF protein expression is similar to transcriptome level, particularly obvious in the typical glioma pathological structure. Multivariate Cox analysis showed that high NSMF expression (HR value: 0.6, 95% CI 0.443–0.813, P=0.001) were independent predictors of long OS. This work revealed that NSMF may be a protective factor for the occurrence and development of gliomas, and can be used as a reliable biomarker for gliomas to diagnose and prompt prognosis of the disease.
Keywords
NSMF, glioma, biomarker, overall survival