Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.846
Application Value of High-Flow Nasal Cannula Therapy in Sequential Treatment of Chronic Obstructive Pulmonary Disease After Weaning from Invasive Mechanical Ventilation
Abstract
Objective: To investigate the application value of high-flow nasal cannula (HFNC) therapy in the sequential treatment of chronic obstructive pulmonary disease (COPD) after weaning from invasive mechanical ventilation.
Methods: A total of 100 COPD patients who were admitted to our hospital from October 2017 to March 2019 were selected and divided into two groups using a random number table (n=50). After weaning from invasive mechanical ventilation, the patients in control group received non-invasive mechanical ventilation, while those in observation group underwent HFNC therapy. The total effective rate, relief time of symptoms, auxiliary oxygen inhalation time, hospital stay, serum inflammatory factors, pulmonary ventilation function indices, arterial blood gas indices and incidence rate of complications were compared between the two groups.
Results: The total effective rate was higher in observation group than that in control group (96.00% vs. 80.00%, P<0.05). The relief time of symptoms such as cough, expectoration and short breath was shorter in observation group than that in control group, and the auxiliary oxygen inhalation time and hospital stay were shorter in observation group than those in control group (P<0.05). After treatment, the levels of C-reactive protein, interleukin-6 and procalcitonin were lower in observation group than those in control group (P<0.05). Besides, after treatment, the forced expiratory volume in one second (FEV1), FEV1 to forced vital capacity ratio, arterial partial pressure of oxygen and blood oxygen saturation level were higher in observation group than those in control group (P<0.05), while the arterial partial pressure of carbon dioxide was lower in observation group than that in control group (P<0.05). The incidence rate of complications was lower in observation group than that in control group (2.00% vs. 14.00%, P<0.05)
Conclusion: After weaning from invasive mechanical ventilation, the adoption of HFNC therapy in sequential treatment can effectively improve the curative effect of COPD patients, accelerating the relief of symptoms, shortening the treatment time, reducing the inflammatory response in the body, improving the pulmonary ventilation function and arterial blood gas status, and also decreasing complications.
Keywords
chronic obstructive pulmonary disease; sequential treatment; non-invasive mechanical ventilation; high-flow nasal cannula therapy