Volume 30, Issue 2, 2021
DOI: 10.24205/03276716.2020.4087
The expression change and significance of inflammatory factors in hypertensive diseases
Abstract
Purpose: To investigate the significance of expression change and the level change of inflammatory cytokines in hypertensive diseases.
Methods: Sixteen spontaneously hypertensive rats were selected, including 6 rats with 8 weeks old (group A) and 6 rats with 16 weeks old (group B); another 12 normal Wistar-Kyoto rats were selected, including 6 rats with 8 weeks old (group C) and 6 rats with 16 weeks old (group D). All rats were male and were fed for 8 weeks. The expression of TNF-?, IL-6, hs-CRP were detected by using ELISA method. At the same time, the blood pressure, the heart weight index and the pathological morphology of the rats were observed.
Results: The levels of IL-6[(259.11±17.88) Pg/ml], TNF-? [(21.57±1.91) Pg/m]and hs-CRP [(1.54±0.34) ng/ml] were significantly higher than the other groups, there was statistically significant difference (P<0.05) in group B; the levels of IL-6 [(201.72±28.91) Pg/ml], TNF-? [(14.33±3.15) Pg/m] and hs-CRP [(1.54±0.34) ng/ml] were significantly higher than that of group C and group D, (P<0.05). In the group A and the group B, the myocardial interstitial cells were massively proliferated, and there was a significant inflammatory infiltration.
Conclusions: With the aggravation of hypertension, the level of serum inflammatory factors was further increased, which suggests that inflammatory factors may play a role in the progression of hypertension, and the severity of hypertension is closely related to the pathological changes of heart.
Keywords
Hypertension; animal experiment; inflammatory factor; tumor necrosis factor; interleukin-6; high sensitivity C reactive protein