Volume 30, Issue 2, 2021
DOI: 10.24205/03276716.2020.4091
Detection of CGRP in plasma and cerebrospinal fluid of neonatal hypoxic-ischemic encephalopathy and its clinical significance
Abstract
Purpose: Neonatal hypoxic-ischemic encephalopathy (HIE) has a high incidence, disability and mortality rate. Calcitonin gene-related peptide (CGRP) exerts a protective role in brain injury. However, whether CGRP plays a role in HIE is unclear. Our study intends to measure
CGRP level in HIE children.
Materials and Method: 93 neonates with HIE were selected as research subjects and 41
cases of neonates admitted to our hospital were selected as control group. The level of
CGRP, calcium-binding protein (S-100?) and neuron-specific enolase (NSE), and NBNA score was measured.
Results: The levels of CGRP, S-100?, and NSE in plasma and cerebrospinal fluid of children with HIE were significantly elevated compared to controls (P <0.05) and gradually increased with the elevated HIE severity (P <0.05). The levels of CGRP, S-100?, and NSE in HIE children in recovery stage were significantly lower than those in acute stage (P <0.05). CGRP levels were positively correlated with S-100? and NSE levels (P <0.05); and negatively correlated with NBNA scores (P <0.05).
Conclusions: Plasma and cerebrospinal fluid CGRP level have clinical significance in the early diagnosis of HIE and assessment of the disease severity
Keywords
HIE; CGRP; plasma; cerebrospinal fluid