Volume 29, Issue 3
DOI: 10.24205/03276716.2020.929
Clinical Value of Combined Detection of Tumor Markers and HPV DNA In the Diagnosis of Cervical Cancer and Precancerous Lesions
Abstract
Objective: Clinical value of combined detection of tumor markers and HPV DNA in the diagnosis of cervical cancer and precancerous lesions. Methods: Select 64 cervical cancer patients admitted to our hospital from December 2017 to December 2018 as the cancer group, 35 patients with precancerous lesions as the precancerous lesion group, and 99 healthy people as the normal group, and compare the tumors of each group The level of markers, the positive rate of different detection methods in CINâ… (mild), CINâ…¡ (moderate), CINâ…¢ (severe) cervical intraepithelial neoplasia and cervical cancer (CIS), comparison of the detection value of different methods, differences The accuracy, specificity, sensitivity, relationship between different ages and HPV infection in HSIL (high-grade squamous intraepithelial lesion) and LSIL (low-grade squamous intraepithelial lesion).Results: Each group has statistical significance among CA125, CYFRA21-1, SCCA, and CA15-3 (P<0.05). Through one-way analysis of variance: the precancerous lesion group and the cancer group have statistical significance compared with the normal group. (P<0.05), but there is no statistical difference between the precancerous lesion group and the cancer group (P>0.05); the positive rate of HPVDNA detection is higher than the positive rates of other tests, which is statistically significant (P<0.05), and Tumor marker detection combined with HPVDNA detection has a high positive rate and high sensitivity. The area under the ROC curve is 0.991, which has a high accuracy, which is higher than other single detections and is statistically significant (P<0.05); TCT combined with HPVDNA detection is in HSIL The accuracy, specificity, and sensitivity of LSIL are higher than that of TCT and HPV DNA testing alone, P<0.05; the HPV positive rate of patients aged 18-27 is higher than that of patients of other age groups, P<0.05. Conclusion: In the early diagnosis of cervical cancer, the accuracy, specificity and sensitivity of tumor markers, TCT combined with HPVDNA detection are relatively high, which can increase the detection rate and has a certain diagnostic value. The two combined detection and screening for cervical cancer and cancer the detection rate of pre-lesion is higher.
Keywords
Tumor markers; HPVDNA; Cervical cancer; Cervical precancerous lesions