Volume 29, Issue 3
DOI: 10.24205/03276716.2020.936
Different Significance of Platelets and Plateletcrit In Adenomyosis And Myoma
Abstract
Purpose: The aim of our study was to investigate the differences of platelet and coagulation function parameters in adenomyosis, uterine leiomyomas and normal people to further explore the meanings of these differences in adenomyosis or uterine leiomyomas.
Methods: A retrospective case-control study was performed. The subjects were divided into adenomyosis group, uterine leiomyomas group and control group. Adenomyosis group included 217 women histological diagnosed after surgery between January 2017 and December 2019. Uterine leiomyomas group included 549 women confirmed by histopathologic examination in the same time and control group included 201 symptomfree women after medical examination. Clinical data, platelet parameters and coagulation function indicators were collected from all patients.
Results: platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), fibrinogen (FIB), D-Dimer and platelet maximum aggregation rate AA (AA:arachidonic acid reagent) were significantly differences among the three groups (P<0.05). PC, PCT, FIB, D-Dimer were significant higher in adenomyosis group compared with control group, while AA was lower in adenomyosis group (P<0.05). PC and PCT were significantly higher in the uterine leiomyomas group than in the control group (P<0.05). Bivariate logist regression analysis showed that PC, PCT, FIB, D-dimer and AA were not risk factors or protective factors for uterine adenomyosis, while PC and PCT were risk factors for uterine leiomyomas.
Conclusion: Our study found that elevated PC and PCT were independent risk factors for uterine leiomyomas, but were not associated with adenomyosis.
Keywords
adenomyosis; leiomyomas; platelet; coagulation function.