Volume 29, Issue 3
DOI: 10.24205/03276716.2020.925
Gene Expression Pattern in Lethal Sepsis and Non-Fatal Sepsis
Abstract
Sepsis is one of the oldest and most complex syndromes in medicine and a common disease with high mortality. Although the treatment of sepsis has attracted attention from people, it still has a high mortality rate. Recent research has focused on exploring the association of genes between lethal sepsis and nonfatal sepsis, while the association mechanism remains unclear. In this study, we explored different expression patterns of genes in lethal sepsis and non-fatal sepsis by analyzing gene expression data sets for lethal sepsis and non-fatal sepsis. As a result, genes up- and down-regulated representative expression pattern in both sepsis while genes and functional levels have opposite phenomena. In non-fatal sepsis, genes down-regulated in lethal sepsis are involved in Toll-like receptor signaling pathways, biologically related processes such as negative regulation of immune responses, and signaling pathways like protein processing in the endoplasmic reticulum. In non-fatal sepsis, genes up-regulated in lethal sepsis are involved in the regulation of the actin-based process, regulation of glucose import, biological processes like protein K48 linked to ubiquitination, and signal processing such as viral myocarditis as well as antigen processing and introduction. In conclusion, our results provide a framework for a comprehensive analysis of the expression patterns of lethal sepsis and non-fatal sepsis to determine effective molecular characteristics for clinical use.
Keywords
lethal sepsis, non-fatal sepsis, genes, biological processes, signaling pathways