Volume 25, Issue 2
DOI: 10.53555/03276716.2016.01
Antibacterial and Antifungal activity of novel naphthyridine derivatives
Abstract
With the rising antimicrobial resistance (AMR) within the microbial populations and limited effectiveness of existing antibiotics, discovery of antimicrobial agents has become crucial across the globe. To this end, we have tested the efficacy of five novel Naphthyridine compounds towards antibacterial and antifungal activity. Among the novel molecules tested, compounds [(8,10-Dibromo-6-phenyl-6a,7,10,12-tetrahydro-1,7,12a-triaza-benzo[a]anthracen-12-one)] displayed better antibacterial and antifungal properties compared to others. Thus, the newly derived molecule may better help in combating microbes which have developed antibiotic in the recent past.
Keywords
Naphthyridines, antimicrobial activity, DNA gyrase