Volume 29, Issue 3
DOI: 10.24205/03276716.2020.728
The Significance of the C-Reactive Protein/Albumin Ratio (CAR) Status in The Perioperative Period of Gastrectomy for Gastric Cancer
Abstract
Background: The postoperative C-reactive protein in the blood has been described to be correlated with the surgical stress (SS) after performing surgery for cancer. However, the diagnostic and predictive values of C-reactive protein/albumin ratio (CAR) still remain obscure. Herein, our purpose to compare the SS by measurement of CAR in patients undergoing laparoscopic and open surgery, and assess the diagnostic value of CAR in prediction of short-term postoperative related complications after gastrectomy. Methods: 116 patients suffering with gastric cancer have gone through curative (R0) gastrectomy between December 2017 and November 2018 in Qingdao Municipal Hospital, with their clinical data retrospectively analyzed. Blood samples were routinely collected to determine perioperative variations of CAR. Univariate and multivariate analyses were conducted to evaluate the risk factors associated with complications of postoperative. The curves of Receiver operating characteristic (ROC) were analyzed to test the threshold values and diagnostic precision of the CAR.
Results: No major difference was observed in CAR between patients undergoing laparoscopic resection and those receiving open resection at baseline and on postoperative day 7. The CAR in laparoscopic group was effectively less as compared to open-surgery group on postoperative days (POD) 1 and 3 (p < 0.001 and = 0.001, respectively), and the optimal predictive CAR threshold of postoperative short-term complications were 2.635 on postoperative day 3. The CAR determined on POD day 3 was pointed as an independent factor for postoperative short-term complications in all patients undergoing gastrectomy. Conclusion: The CAR status is not only accurate assessment of SS but may also serve as a reliable indicator of postoperative short-term complications for patients suffering with gastric cancer after gastrectomy.
Keywords
C-reactive protein, albumin ratio, surgical stress gastrectomy