Volume 29, Issue 5, 2020
DOI: 10.24205/03276716.2020.1130
Effect of rapamycin combined with nedaplatin in the treatment of bladder cancer and its influence on angiogenesis and invasion
Abstract
Objective To investigate the efficacy of rapamycin combined with nedaplatin in the treatment
of bladder cancer and its influence on angiogenesis and invasion. Methods 96 cases of bladder
cancer patients in our hospital and Shanghai Fudan clinical pathological diagnosis center from
January 2015 to December 2019 were retrospectively analyzed. They were divided into two
groups according to different preoperative chemotherapy methods, 48 cases in each group.
The observation group was given rapamycin combined with nedaplatin chemotherapy, while
the control group was only given nedaplatin chemotherapy. After 2 cycles of continuous
chemotherapy, extensive hysterectomy and pelvic lymph node dissection were implemented.
The clinical efficacy, surgical conditions, microvessel density (MVD), vascular endothelial
growth factor (VEGF), type 1, 3a, 8 and β - Catenin in pathological and healthy tissues were
compared between the two groups. Result After treatment, the total remission rate of the
observation group was 77.08% (37/48), which was significantly higher than 52.08% (25/48) of
the control group (P < 0.05); there was no significant difference in the operation time and
intraoperative blood loss between the two groups (P>0.05). The rates of vascular invasion,
parauterine invasion and lymph node metastasis in the observation group were 2.08% (1/48),
4.17% (2/48), 4.17% (2/48), which were significantly lower than 14.58% (7/48) of the control
group). MVD and VEGF in the lesions of the two groups were significantly higher than those
in the healthy tissues (P < 0.05), but the MVD and VEGF in the lesion tissues of the observation
group were significantly lower than those in the control group, and the Pearson correlation
analysis showed that there was a positive correlation between MVD and VEGF (P<0.05); Wnt1,
Wnt3a, wnt8 and β - Catenin in in the lesion tissues of the two groups were significantly higher
than those in the healthy group However, the levels of Wnt1, Wnt3a, wnt8 and β - Catenin in
the lesion tissues of the observation group were significantly lower than those of the control
group (P < 0.05); there were no grade III to IV liver and kidney injury in the two groups during
the treatment, and there was no significant difference in the incidence of bone marrow
suppression and gastrointestinal reaction between the two groups (P>0.05). Conclusion
rapamycin combined with nedaplatin has a significant effect in bladder cancer patients, which
can effectively regulate tumor angiogenesis and cancer cell invasion, and improve the disease
remission rate, with less side effects and high safety
Keywords
bladder cancer; rapamycin; nedaplatin; angiogenesis; invasiveness